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Owing to the absence of foxp3a-positive Treg cells in the differentiating testis of foxp3a-/- mutants, abundant T cells and macrophages expand to disrupt an immunosuppressive milieu, resulting in defective development of germ cells and gonadal somatic cells and leading to development of infertile males. Therefore, our study reveals that foxp3a-positive Treg cells play an essential role in the orchestration of gonadal development and sex differentiation in zebrafish. Malnutrition is frequent in patients with heart failure (HF) and contri
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