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We explain the synthesis plus in vitro activity of drug-dye conjugate 1, that will be a mix of the PARP inhibitor rucaparib and heptamethine cyanine dye IR-786. The drug-dye conjugate 1 had been assessed in three different patient-derived glioblastoma cellular lines and showed powerful cytotoxic activity with nanomolar effectiveness (EC50 128 nM), that was a 780 fold improvement over rucaparib itself. We also observe a synergistic effectation of 1 with temozolomide (TMZ), t
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