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Measurements of transverse 15N spin relaxation prices expose a decrease in the amplitudes and/or timescales of backbone N-H relationship motions, corresponding to a rigidification of this six-helix bundles. Overall, our data reveal that inhibition of HIV-1 maturation by BVM involves alterations in structure and dynamics which can be remarkably delicate, but nonetheless enough to make a large influence on CA-SP1 cleavage.The Great Unconformity marks an important space into the con
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