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The optimal path finds the protonation of residue H26 close to the channel entry favourable for lowering the change energies of subsequent measures, in particular, starting for the Asn gate and development of a hydrogen-bonded string. Residue Y33 plays an important role in shuttling the transferred proton hole. CONCLUSIONS the suitable pathway found by the change network approach reveals exactly the same essential traits as paths determined earlier by other techniques. The computed
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