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8% was achieved from data benchmarking. The results of this study indicate that the MCNPX code can be used as a valid tool for dose measurement in the presence of nanoparticles. Moreover, tissue types of tumor as an environmental feature, alongside with the nanoparticle's size and concentration as well as the conditions of radiotherapy, should be considered in the dose calculation. The results of this study indicate that the MCNPX code can be used as a valid tool for dose measurement in the presence of nanoparticles. Moreover, tissue t
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