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proband, the risk to sibs is 50%. Once the ACVR1 pathogenic variant has been identified in an affected family member, prenatal testing for a pregnancy at increased risk and preimplantation genetic testing are possible.At present, there exists a wide range of diagnostic tests available in the diagnosis of Diverticular Disease. This can give rise to significant regional variability in practice between clinical centres; as well as locally between different patient cohorts. The choice of test used may depend on a variety of both clinical and
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