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© 2020 Viol et al.OBJECTIVES An unexpected drug-drug interaction has been recently reported between dolutegravir, an HIV integrase inhibitor, and valproic acid. Despite there being several potential underlying mechanisms, plasma protein displacement has been suggested. The aim of this study was to assess plasma concentrations of several antiretrovirals when administered with or without valproic acid. METHODS We performed a therapeutic drug monitoring registry analysis and identified patients concomitantly taking antiretrovirals and valpr
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