https://www.selleckchem.com/pr....oducts/pin1-inhibito
Based on the final mPBPK model with TMDD and assuming a weight of 70 kg for an adult human, a minimal inhibition (95%) at 10 mg/kg garadacimab were predicted. The phase I study is complete, and data on exposure profiles and inhibition of FXIIa-mediated kallikrein activity observed in the trial support and validate these simulations. This emphasizes the utility and relevance of translational modeling and simulation in drug development.The core symptoms of autism spectrum disorder (ASD) mainly relate to social communication a
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