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We report an updated subgroup analysis of POLLUX predicated on cytogenetic danger. The cytogenetic risk ended up being determined making use of fluorescence in situ hybridization/karyotyping; patients with high cytogenetic threat had t(4;14), t(14;16), or del17p abnormalities. Minimal residual disease (MRD; 10-5) was considered via the clonoSEQ® assay V2.0. 569 clients were randomized (D-Rd, n = 286; Rd, n = 283); 35 (12%) clients per team had large cytogenetic danger. After a median follow-up of 44.3
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