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The oral median lethal dose (LD ) of MECH was found to be higher than 5000mg/kg. There were significant (p0.05) decrease in the charcoal movement in the mice treated with the MECH (1000mg/kg) and loperamide (5mg/kg). The pretreatment of the mice with naloxone, prazosin and propranolol each significantly (p0.05) reversed the antidiarrhoeal activity produced by MECH. The results obtained in this study suggest the probable involvement of opioidergic and (α and β)-adrenergic systems in the antidiarrhoeal activity of the methanol leaf
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