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difficult to interpret. One must be cautious about adducing evidence from such published reports of old animal data sets. Proton-density fat-fraction (PDFF) is typically measured from PDFF maps by calculating the mean PDFF value within a region of interest (ROI). However, the mean estimator has been shown to result in bias when signal-to-noise ratio (SNR) is low, resulting from a skewed distribution of PDFF noise statistics. Thus, the purpose of this work was to determine the relative performance of three estimation methods (mean, media
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