https://www.selleckchem.com/pr....oducts/remdesivir.ht
Surprisingly, adult AgtAgrp-KO mice exhibited normal circulating AGT protein and hepatic Agt mRNA expression, but reduced Agt mRNA expression in adrenal glands. Reanalysis of RNAseq datasets describing transcriptomes of normal adrenal glands suggests that Agrp and Alb are both expressed in this tissue, and fluorescent reporter gene expression confirms Cre activity in adrenal gland of both Agrp-Cre and Alb-Cre mice. These findings lead to the iconoclastic conclusion that extrahepatic (ie - adrenal) expression of Agt is critically requ
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