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For a long period, HSPGs were believed to take place in the build up as an innocent bystander. Yet, the consistent existence of HSPGs in various deposits, no matter what the amyloid species, resulted in the theory that these macromolecular glycoconjugates might play practical roles within the pathological means of amyloidosis. In vitro studies have revealed that HSPGs, or even more exactly, the heparan sulfate (HS) side chains communicate with amyloid pept
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