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pathological anxiety and sporadic Alzheimer's disease (AD). In rats posted to chronic restraint anxiety, cortical CB1 R density ended up being dramatically decreased, as evaluated with radioligand binding. Nevertheless, 4-NPB hydrolysis remained at control amounts. Nevertheless, in rats 4 weeks after intracerebroventricular injection with streptozotocin - a well established type of sporadic advertisement -, both CB1 roentgen levels and 4-NPB hydrolysis and its DAGL- and MAGL-dependent fractions
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