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Co-culture of CD206+ cells with DCs showed that IL-12 production was suppressed in DCs concurrent with the decline of the MHC class IIhiCD86+ population, which was restored by neutralization of IL-10. These results demonstrate SLM CD206+ cells show the feature of tolerogenic macrophages and down-regulate the APC function of mature DCs resulting in the inhibition of CD4+ T cell responses. © The Japanese Society for Immunology. 2020. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.OBJECTIVES INSM1 has been described as a sensi
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