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The therapeutic expediency of cisplatin was limited due to its nephrotoxic side effects, so this study planned to assess the nephrotic and neuroprotective impact of metformin (MET) and low-dose radiation (LDR) in cisplatin-prompted kidney injury and uremic encephalopathy (UE). The effect of the 10-day MET treatment (200mg/kg, orally) and/or fractionated LDR (0.25Gy, of the total dose of 0.5Gy, 1st and 7th day, respectively) on (5mg/kg, intraperitoneally) cisplatin as a single dose was administered at the 5th day. Serum urea, creatinine
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