https://www.selleckchem.com/products/cc-930.html
Activation of TrkC by Nt-3 resulted in phosphorylation of the Igf1R on activating tyrosine residues in podocytes. Igf1R phosphorylation was increased in mouse kidneys while it was decreased in kidneys. Furthermore, expression was elevated in glomerular tissue of patients with diabetic kidney disease compared with control glomerular tissue. Our results show that is essential for maintaining glomerular integrity. Furthermore, TrkC modulates Igf-related signaling in podocytes. Our results show that TrkC is essential for maintaining glomerul
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