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Extracellular Tau might be definitely released by one cellular then adopted by adjacent cells, causing the cell-to-cell transmission of Tau. Acquiring proof has shown that Tau propagation is not just because of the trans-synaptic spreading but additionally via exo-synaptic spreading pathways especially beneath the pathological conditions. Among these, exosomes, microvesicles and tunneling nanotubes (TNTs) tend to be proposed exo-synaptic paths for the spread of Tau pathology. These results have a
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