https://meksignal.com/index.ph....p/overcoming-the-lim
PvDBP gene amplification leads to increased mRNA levels and shields P. vivax in vitro against invasion inhibitory real human monoclonal antibodies targeting a conserved binding domain of DBP. Individual examples suggest that parasites with an increase of pvdbp copy number are able to infect those with naturally obtained antibodies extremely preventing the binding of PvDBP into the Duffy receptor. These outcomes reveal that gene content number variation impact the parasite's ability to evade anti-PvDBP
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