https://kinasepathway.com/2024..../10/23/organophospha
Our analysis leads to leading axioms of intragenic duplication and pseudo-symmetric assembly of ancestral transmembrane helical protodomains, composed of 3 (or 4) helices. A parallel deconstruction and reconstruction of those domains provides a structural and mechanistic framework with their evolutionary routes. It highlights the conformational plasticity inherent to fold formation itself, the role of structural also functional constraints in shaping that fold, as well as the
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