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BACKGROUND. The mechanisms linking cardiovascular disease (CVD) and depression are still not established. We investigated the impact of mental vulnerability on the relationship between CVD and depression. METHODS. A total of 19,856 individuals from five cohorts of random samples of the background population in Copenhagen were followed from baseline (1983-2011) until 2017 in Danish registries. Additive hazard and Cox proportional hazard models were used to analyze the effects of confounding by mental vulnerability as well as interactions
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