https://www.selleckchem.com/pr....oducts/epertinib-hyd
5 channel arose primarily from its open-channel blocking action. The inhibitory action of desflurane or sevoflurane on hKv1.5 channel was significantly attenuated in T480A, V505A and I508A mutant channels, compared with wild-type channel. Computational docking simulation predicted that desflurane or sevoflurane resides within the inner cavity of channel pore and has contact with Thr479, Thr480, Val505 and Ile508. Conclusion and implications Desflurane and sevoflurane exert an open-channel blocking action on hKv1.5 channe
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