https://www.selleckchem.com/pr....oducts/idasanutlin-r
Objectives Complete responses have been observed in NPM1-mutated AML patients with dactinomycin, a nucleolar stress-inducing drug. Here, we report a single-center experience of compassionate use of dactinomycin in untreated or relapsed/ refractory NPM1-mutated AML. Methods From September 2015 to February 2019, 26 adult patients with NPM1-mutated AML received dactinomycin in different situations front-line treatment in 4 unfit patients (16%); morphologic (n = 16, 62%), molecular relapses (n = 4, 16%), refractory disease (n =
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