https://www.selleckchem.com/pr....oducts/hpk1-in-2.htm
MMR deficiency was detected in 20.6% (44/213). Methylation analysis was performed in 27 patients of whom, 22 (81.4%) showed MLH1 promoter hypermethylation. Only 9% of MMR deficient patients were identified as at risk for Lynch syndrome by the revised Bethesda/German-DKG criteria. A pathogenic germline mutation was discovered in 3 out of 20 patients that underwent genetic testing. None of these patients were younger than 50years or had a family history of Lynch syndrome-associated malignancies. General MMR assessment is a feasible stra
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