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Conclusions The presence of high grade RLS is associated with reduced vasodilatory CVMR in migraineurs. Further decrease of CVMR of PCA upon aerogenic microemboli passage may support the mechanism of 'facilitation with subclinical cerebral ischemia caused by microembolism', hypothesis explaining the onset of migraine. Abbreviations BHI Breath-holding index; BHT Breath Holding Test; CVMR Cerebral vasomotor reactivity; EDV End-diastolic velocity; HIT-6 Headache Impact Test; HPV Hyperventilation; MCA Middle cerebral artery; MIDAS migraine di
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