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14, post 47 ± 31%, P = 0.94; HF-rEF, pre 109 ± 47, post 139 ± 150%, P = 0.76) response to stretch. Similarly, in SHAM and HF-rEF rats, we found that the TxA2 -R antagonist had no effect on the peak ΔMAP (SHAM n = 7, pre 13 ± 7, post 19 ± 14, P = 0.15; HF-rEF n = 14, pre 24 ± 13, post 21 ± 13 mmHg, P = 0.47) or peak ΔRSNA (SHAM pre 52 ± 43, post 57 ± 67%, P = 0.94; HF-rEF, pre 108 ± 93, post 88 ± 72%, P = 0.3 response to stretch. The data do not support a role for EP4-Rs or TxA2 -Rs in the chronic mechanoreflex sensitization in HF-rEF
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