https://www.selleckchem.com/ph....armacological_epigen
Thus, FXN loss can lead to lower lean mass, with ISR activation, both of which are insensitive to exercise training.Gene therapy involves a substantial loss of hematopoietic stem and progenitor cells (HSPC) during processing and homing. Intra-BM (i.b.m.) transplantation can reduce homing losses, but prior studies have not yielded promising results. We studied the mechanisms involved in homing and engraftment of i.b.m. transplanted and i.v. transplanted genetically modified (GM) human HSPC. We found that i.b.m. HSPC transplant
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