https://www.selleckchem.com/pr....oducts/aebsf-hcl.htm
74 nmol/L) displayed subnanomolar affinity for AR . The p.H875Y mutation selectively increased sensitivity of the AR for 11KT (EC50 0.15 nmol/L, p 0.05 vs AR ), whereas p.L702H decreased sensitivity for 11KT by almost 50-fold. While cortisol and prednisolone both stimulate AR , dexamethasone importantly does not. Both testosterone and 11KT effectively contribute to AR activation, while selective sensitization positions 11KT as a more prominent activator of AR . Dexamethasone may be a suitable alternative to prednisolone and shoul
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