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This wear-off occurrence may adversely affect well being of chronic migraine patients under OnabotA therapy. The ultimate way to counteract wear-off stays to be determined. Current medications are inadequate in approximately one-third of men and women with epilepsy. Therefore, new antiseizure medicines are urgently needed to address this problem of pharmacoresistance. Nevertheless, traditional rodent seizure and epilepsy models are poorly suited to high-throughput chemical evaluating. M
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