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Recognition of the agents most commonly implicated in causing methemoglobinemia can provide context for making therapeutic decisions and inform the diagnostic process. We evaluated the etiologic agents most commonly implicated in clinically significant methemoglobinemia using data from the National Poison Data System (NPDS). What are the most frequent etiologic agents associated with clinically significant methemoglobinemia. This was a retrospective cross-sectional chart review using electronic data from the NPDS. The NPDS database was
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