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67) were associated with improved PFS (all, 0.05). In 15 biomarker combinations, six combinations exhibited a discriminatory ability of 20% for the 4.5-year PFS rate, with four based on PD-L2 (PARP, PTEN, CD4, and PD-L1, 20.5-30.0%). Increased PD-L2 expression is a prognostic marker of decreased survival in EOC. Interaction between tumor DNA repair and microenvironment determines tumor progression and survival. Increased PD-L2 expression is a prognostic marker of decreased survival in EOC. Interaction between tumor DNA repair and
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