https://www.selleckchem.com/pr....oducts/CP-673451.htm
The analgesic potency of morphine-6-glucuronide (M6G) has been shown to be 50-fold higher than morphine after intracerebral injection. However, the brain penetration of M6G is significantly lower than morphine, thus limiting its usefulness in pain management. Here, we created new entities by the conjugation of the Angiopep-2 peptide (An2) that crosses the blood-brain-barrier (BB by LRP1 receptor-mediated transcytosis, with either morphine or M6G. We demonstrated improvement of BBB permeability of these new entities compared with tha
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