https://www.selleckchem.com/pr....oducts/NVP-AEW541.ht
The GlcNAc unit observed in subsite -1 makes exclusive hydrogen bonds to the conserved residues Arg274, Tyr530, Asp532 and Glu584, while Trp487, Trp546, Trp582 and Trp505 form a hydrophobic wall around the -1 GlcNAc. The catalytic mutants D437A/N and E438A/Q exhibited a drastic loss of GlcNAcase activity, confirming the catalytic role of the acidic pair (Asp437-Glu438).Statistical likelihood maximization is currently one of the main tools in computational procedures in biological crystallography. In these procedures, the likelihood f
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