https://www.selleckchem.com/pr....oducts/nor-noha-dihy
The persistent IDO degradation blocks tryptophan (Trp)-catabolism program and promotes the activation of effector T cells. Such a SPNpro-mediated in-situ immunometabolic intervention synergizes immunogenic phototherapy to boost the antitumor T-cell immunity, effectively inhibiting tumor growth and metastasis. Thus, this study provides a polymer platform to advance PROTAC in cancer therapy.The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mic
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