https://www.selleckchem.com/pr....oducts/pirtobrutinib
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a 5-year survival rate of less then 8%. Unsupervised clustering of 76 PDAC patients based on intron retention (IR) events resulted in two clusters of tumors (IR-1 and IR-2). While gene expression-based clusters are not predictive of patient outcome in this cohort, the clusters we developed based on intron retention were associated with differences in progression-free interval. IR levels are lower and clinical outcome is worse in IR-1 compared with IR-2.
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