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This work advances the understanding of the molecular evolution of diatom plastomes and provides a foundation for future studies.Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric acute lymphoblastic leukemia. Recently, NUDT15 variants were identified as a major determinant of mercaptopurine intolerance. Two NUDT15 variants, c.36_37insGGAGTC and c.415C T, are located on exons 1 and 3, respectively. Patients with heterozygous c.36_37insGGAGTC and c.415C T can be either compound heterozygo
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