https://www.selleckchem.com/pr....oducts/mpp-dihydroch
The selective RIPK2 inhibitor WEHI-345 blocked tumor-cell invasion in vitro and reduced metastatic burden in vivo. In conclusion, our results indicate that gefitinib blocks macrophage-promoted invasion and metastatic extravasation by reprogramming macrophages through inhibition of RIPK2. Copyright ©2020, American Association for Cancer Research.NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma that is driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin through its
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