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We present clinical, genetic, and functional data supporting a causative role of the SNCA c.215CT (p.Thr72Met) variant in familial PD. Testing for this variant in patients with PD, especially of Turkish origin, might detect additional carriers. Further functional analyses might offer new insights into the shared biochemical properties of the PD-causing SNCA missense variants, and how they lead to neurodegeneration. T (p.Thr72Met) variant in familial PD. Testing for this variant in patients with PD, especially of Turkish origin, migh
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