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tive metabolic effect and minimal side effect profile. Clinical Trial Registration www.ClinicalTrials.gov, Study Identification NCT03598673.Objective Catheter ablation combined with left atrial appendage closure (LAAC) has emerged as a promising strategy for atrial fibrillation (AF) patients at high risk for stroke or with contraindications for oral anticoagulants (OACs). But the evidence for the long-term safety and efficacy of a combined procedure using cryoballoon ablation (CBA) with LAAC is still insufficient. Methods From October 201
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