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Their reactivity in a Negishi cross-coupling reaction was tested. An example of the one-pot reaction sequence of Negishi and Suzuki-Miyaura cross-couplings for synthesis of combretastatin A4 is also presented.Protein fragmentation is a critical component of top-down proteomics, enabling gene-specific protein identifi-cation and full proteoform characterization. The factors that influence protein fragmentation include precursor charge, structure, and primary sequence which have been explored extensively for collision-induced dissociation
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