https://www.selleckchem.com/pr....oducts/epz015666.htm
Following influenza infection, rs2248374-G ERAP2 expressing cells may transcribe an alternative spliced isoform ERAP2/Iso3. This variant, unlike ERAP2-wt, is unable to trim peptides to be loaded on MHC class I molecules, but it can still dimerize with both ERAP2-wt and ERAP1-wt, thus contributing to profiling an alternative cellular immune-peptidome. In order to verify if the expression of ERAP2/Iso3 may be induced by other pathogens, PBMCs and MDMs isolated from 20 healthy subjects were stimulated with flu, LPS, CMV, HIV-AT-2, SARS-C
Like
Comment
Share
