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Eventually, we analyzed the association of a dominant-negative polymorphism in TLR5 (rs5744168) with symptoms of asthma signs in customers with symptoms of asthma. RESULTS We showed that microbial flagellin are available in the house dust of patients with asthma and therefore this microbial product exacerbates sensitive airway irritation in an allergen-specific mouse model of asthma. Moreover, a dominant-negative hereditary polymorphism in TLR5, the receptor for flagellin, is associa
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