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All variants were located in a Tn1403-related transposon, containing - - , and - gene cassette arrays, respectively. Notably, the producer showed a high MIC level of meropenem (MIC64 mg/L). Compared to , was found a G-to-T transversion at position 350, leading to a phenylalanine-for-valine substitution in position 117, which is closer to leucine155 in the omega loop of the active site. MIC of meropenem for DH5α with the recombinant plasmid pHSG398 carrying was elevated by 8 times. We speculate that the OXA-10-like enzymes and the decr
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