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In MC 1, BMF was lower than endplates without MC (absolute difference -22.3%; p 0.001); in MC 2, BMF was higher (absolute difference 21.0%; p 0.001). Absolute BMF differences between affected and unaffected marrow were larger in patients with greater disability (p = 0.029-0.032) and were not associated with pain (p = 0.49-0.83). BMF is significantly altered in MC. Water-fat MRI enables BMF measurements that may eventually form the basis for quantitative assessments of MC severity and progression. BMF is significantly altered in MC
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