https://www.selleckchem.com/products/azd6738.html
Herein, we report the design, synthesis and evaluation of novel bioinspired imidazo[1,2-a4,5c']dipyridines. The structural optimization identified four anti-proliferative compounds. Compounds 11, 18, 19 and 20 exhibited excellent anticancer activities in vitro with IC50 of 0.4-5 μM against three human cancer cell lines (MDA-MB-468, MDA-MB-435s and MDA-MB-231). These four compounds induced apoptosis in MDA-MB-231 cells in a dose-dependent manner, targeting different apoptotic proteins expression 11 increased the expression of pro-apoptot
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