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To assess the influence of multiple uses on the cyclic flexural fatigue and torsional resistance of Reciproc R25 (REC) instruments. 256 canals (2 for each mandibular molar) were prepared using Reciproc R25 instruments. A total of 96 25-mm-long Reciproc R25 instruments were divided in six groups (n=8) on the basis of different number of canal shaped new instruments (control group), 1, 2, 3, 4 or 6 canals shaped during simulated clinical use for other groups respectively. Sixteen files were used for each of the six groups (8 instruments fo
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