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05). A significant improvement in expression of gene and antioxidant enzyme levels were observed compared to pre-treatment by NAC (P0.05). Significant correlations were observed between NRF2 mRNA expression level, specific sperm parameters and level of antioxidant enzymes (P0.05). The results demonstrated that NAC oral supplementation protected against oxidative stress by enhancing NRF2 expression. This could improve semen parameters quality parameters in asthenoteratozoospermia men (Registration number IRCT20170830035998N4). The
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