https://p53signals.com/index.p....hp/the-function-asso
Substrate binding to ProTQQQ caused allosteric tightening of this affinity of most SC(1-246) variants, in line with zymogen activation through profession associated with specificity pocket. Conventional changes at opportunities 1 and 2 had been well accepted, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation strength much like wild-type SC(1-246). Weaker binding variations typically had reduced activation rates, although at near-saturating ProTQQ
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