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Finding the Best ADHD Medication For Adults Stimulants like methylphenidate (Ritalin) or amphetamine (Vyvanse), work quickly to increase and stabilize levels of brain chemicals. These drugs can trigger weight fluctuations, tics, and sleep problems in some people. Atomoxetine as well as certain antidepressants (like bupropion) are non-stimulant drugs that work slowly to assist with ADHD symptoms. They boost norepinephrine, which is a chemical in the brain that helps control impulses and improve concentration. Stimulants ADHD medication is often the most effective
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