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Currently no vaccine is developed to immunize humans against this condition. The most important difficulties with the present medications would be the improvement resistance and their undesireable effects. Therefore, discover a good urge to research and design drugs having better efficacies and reduced toxicities as compared to present chemotherapy drugs. Leishmania has various enzymes involved with its metabolic paths that are special to either similar genus or trypanosomatids making all of them a

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